Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing

After damage to the adult mammalian central nervous system (CNS), surviving neurons have limited capacity to regenerate and restore functional connectivity. Conditional genetic deletion of PTEN results in robust CNS axon regrowth, while PTEN repression with short hairpin RNA (shRNA) improves regener...

Descripción completa

Detalles Bibliográficos
Autores principales: Moses, C., Hodgetts, S. I., Nugent, F., Ben-Ary, G., Park, K. K., Blancafort, P., Harvey, A. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347541/
https://www.ncbi.nlm.nih.gov/pubmed/32647121
http://dx.doi.org/10.1038/s41598-020-68257-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347541/
https://www.ncbi.nlm.nih.gov/pubmed/32647121
http://dx.doi.org/10.1038/s41598-020-68257-y

Ejemplares similares