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Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing
After damage to the adult mammalian central nervous system (CNS), surviving neurons have limited capacity to regenerate and restore functional connectivity. Conditional genetic deletion of PTEN results in robust CNS axon regrowth, while PTEN repression with short hairpin RNA (shRNA) improves regener...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347541/ https://www.ncbi.nlm.nih.gov/pubmed/32647121 http://dx.doi.org/10.1038/s41598-020-68257-y |