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Polymerized human hemoglobin facilitated modulation of tumor oxygenation is dependent on tumor oxygenation status and oxygen affinity of the hemoglobin-based oxygen carrier
Administration of hemoglobin-based oxygen carriers (HBOCs) into the systemic circulation is a potential strategy to relieve solid tumor hypoxia in order to increase the effectiveness of chemotherapeutics. Previous computational analysis indicated that the oxygen (O(2)) status of the tumor and HBOC O...
Autores principales: | Belcher, Donald A., Lucas, Alfredo, Cabrales, Pedro, Palmer, Andre F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347553/ https://www.ncbi.nlm.nih.gov/pubmed/32647211 http://dx.doi.org/10.1038/s41598-020-68190-0 |
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