Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries

Schwann cell grafts support axonal growth following spinal cord injury, but a boundary forms between the implanted cells and host astrocytes. Axons are reluctant to exit the graft tissue in large part due to the surrounding inhibitory environment containing chondroitin sulphate proteoglycans (CSPGs)...

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Detalles Bibliográficos
Autores principales: Warren, Philippa M., Andrews, Melissa R., Smith, Marc, Bartus, Katalin, Bradbury, Elizabeth J., Verhaagen, Joost, Fawcett, James W., Kwok, Jessica C. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347606/
https://www.ncbi.nlm.nih.gov/pubmed/32647242
http://dx.doi.org/10.1038/s41598-020-67526-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347606/
https://www.ncbi.nlm.nih.gov/pubmed/32647242
http://dx.doi.org/10.1038/s41598-020-67526-0

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