LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis

The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear, and this lack of clarity is detrimental to efforts to identify therapeutic targets. Here we show that chondrocytes under inflammatory conditions undergo a metabolic shift that is regulated by NF-κB activati...

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Detalles Bibliográficos
Autores principales: Arra, Manoj, Swarnkar, Gaurav, Ke, Ke, Otero, Jesse E., Ying, Jun, Duan, Xin, Maruyama, Takashi, Rai, Muhammad Farooq, O’Keefe, Regis J., Mbalaviele, Gabriel, Shen, Jie, Abu-Amer, Yousef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347613/
https://www.ncbi.nlm.nih.gov/pubmed/32647171
http://dx.doi.org/10.1038/s41467-020-17242-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347613/
https://www.ncbi.nlm.nih.gov/pubmed/32647171
http://dx.doi.org/10.1038/s41467-020-17242-0

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