Silencing miR-370-3p rescues funny current and sinus node function in heart failure

Bradyarrhythmias are an important cause of mortality in heart failure and previous studies indicate a mechanistic role for electrical remodelling of the key pacemaking ion channel HCN4 in this process. Here we show that, in a mouse model of heart failure in which there is sinus bradycardia, there is...

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Detalles Bibliográficos
Autores principales: Yanni, Joseph, D’Souza, Alicia, Wang, Yanwen, Li, Ning, Hansen, Brian J., Zakharkin, Stanislav O., Smith, Matthew, Hayward, Christina, Whitson, Bryan A., Mohler, Peter J., Janssen, Paul M. L., Zeef, Leo, Choudhury, Moinuddin, Zi, Min, Cai, Xue, Logantha, Sunil Jit R. J., Nakao, Shu, Atkinson, Andrew, Petkova, Maria, Doris, Ursula, Ariyaratnam, Jonathan, Cartwright, Elizabeth J., Griffiths-Jones, Sam, Hart, George, Fedorov, Vadim V., Oceandy, Delvac, Dobrzynski, Halina, Boyett, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347645/
https://www.ncbi.nlm.nih.gov/pubmed/32647133
http://dx.doi.org/10.1038/s41598-020-67790-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347645/
https://www.ncbi.nlm.nih.gov/pubmed/32647133
http://dx.doi.org/10.1038/s41598-020-67790-0

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