A model-based analysis of phenytoin and carbamazepine toxicity treatment using binding-competition during hemodialysis

Hemodialysis (HD) has limited efficacy towards treatment of drug toxicity due to strong drug-protein binding. In this work, we propose to infuse a competitor drug into the extracorporeal circuit that increases the free fraction of a toxic drug and thereby increases its dialytic removal. We used a me...

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Detalles Bibliográficos
Autores principales: Maheshwari, Vaibhav, Hoffman, Robert S., Thijssen, Stephan, Tao, Xia, Fuertinger, Doris H., Kotanko, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347918/
https://www.ncbi.nlm.nih.gov/pubmed/32647294
http://dx.doi.org/10.1038/s41598-020-68333-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347918/
https://www.ncbi.nlm.nih.gov/pubmed/32647294
http://dx.doi.org/10.1038/s41598-020-68333-3

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