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A model-based analysis of phenytoin and carbamazepine toxicity treatment using binding-competition during hemodialysis
Hemodialysis (HD) has limited efficacy towards treatment of drug toxicity due to strong drug-protein binding. In this work, we propose to infuse a competitor drug into the extracorporeal circuit that increases the free fraction of a toxic drug and thereby increases its dialytic removal. We used a me...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347918/ https://www.ncbi.nlm.nih.gov/pubmed/32647294 http://dx.doi.org/10.1038/s41598-020-68333-3 |