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Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid

Background: In Alzheimer’s disease (AD) neuronal degeneration is associated with gliosis and infiltration of peripheral blood mononuclear cells (PBMCs), which participate in neuroinflammation. Defects at the blood-brain barrier (BBB) facilitate PBMCs migration towards the central nervous system (CNS...

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Detalles Bibliográficos
Autores principales: Spampinato, Simona Federica, Merlo, Sara, Fagone, Evelina, Fruciano, Mary, Sano, Yasuteru, Kanda, Takashi, Sortino, Maria Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347984/
https://www.ncbi.nlm.nih.gov/pubmed/32719583
http://dx.doi.org/10.3389/fnmol.2020.00120