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microRNA125对无义突变的人凝血因子Ⅸ基因调控的分子机制
OBJECTIVE: To construct human coagulation factor Ⅸ mini-gene (Mini-hF9) and some nonsense mutants, detect the levels of the Mini-hF9 mRNA, and analyze the molecular mechanism of microRNA125 regulating F9 gene with nonsense mutation. METHODS: Three nonsense mutants were obtained by using PCR mutagene...
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
| Publicado: |
Editorial office of Chinese Journal of Hematology
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348302/ https://www.ncbi.nlm.nih.gov/pubmed/27210873 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2016.05.007 |