CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy

Voltage-gated ClC-2 channels are essential for chloride homeostasis. Complete knockout of mouse ClC-2 leads to testicular degeneration and neuronal myelin vacuolation. Gain-of-function and loss-of-function mutations in the ClC-2-encoding human CLCN2 gene are linked to the genetic diseases aldosteron...

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Detalles Bibliográficos
Autores principales: Fu, Ssu-Ju, Hu, Meng-Chun, Peng, Yi-Jheng, Fang, Hsin-Yu, Hsiao, Cheng-Tsung, Chen, Tsung-Yu, Jeng, Chung-Jiuan, Tang, Chih-Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348978/
https://www.ncbi.nlm.nih.gov/pubmed/32466489
http://dx.doi.org/10.3390/cells9061332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348978/
https://www.ncbi.nlm.nih.gov/pubmed/32466489
http://dx.doi.org/10.3390/cells9061332

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