Therapeutic Editing of the TP53 Gene: Is CRISPR/Cas9 an Option?

The TP53 gene encodes the transcription factor and oncosuppressor p53 protein that regulates a multitude of intracellular metabolic pathways involved in DNA damage repair, cell cycle arrest, apoptosis, and senescence. In many cases, alterations (e.g., mutations of the TP53 gene) negatively affect th...

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Detalles Bibliográficos
Autores principales: Mirgayazova, Regina, Khadiullina, Raniya, Chasov, Vitaly, Mingaleeva, Rimma, Miftakhova, Regina, Rizvanov, Albert, Bulatov, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349023/
https://www.ncbi.nlm.nih.gov/pubmed/32630614
http://dx.doi.org/10.3390/genes11060704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349023/
https://www.ncbi.nlm.nih.gov/pubmed/32630614
http://dx.doi.org/10.3390/genes11060704

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