Computational Model Reveals a Stochastic Mechanism behind Germinal Center Clonal Bursts

Germinal centers (GCs) are specialized compartments within the secondary lymphoid organs where B cells proliferate, differentiate, and mutate their antibody genes in response to the presence of foreign antigens. Through the GC lifespan, interclonal competition between B cells leads to increased affi...

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Detalles Bibliográficos
Autores principales: Pélissier, Aurélien, Akrout, Youcef, Jahn , Katharina, Kuipers , Jack, Klein , Ulf, Beerenwinkel, Niko, Rodríguez Martínez , María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349200/
https://www.ncbi.nlm.nih.gov/pubmed/32532145
http://dx.doi.org/10.3390/cells9061448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349200/
https://www.ncbi.nlm.nih.gov/pubmed/32532145
http://dx.doi.org/10.3390/cells9061448

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