Bromodomain Protein BRD4 Accelerates Glucocorticoid Dysregulation of Bone Mass and Marrow Adiposis by Modulating H3K9 and Foxp1

Glucocorticoid provokes bone mass loss and fatty marrow, accelerating osteoporosis development. Bromodomain protein BRD4, an acetyl–histone-binding chromatin reader, regulates stem cell and tissue homeostasis. We uncovered that glucocorticoid inhibited acetyl Lys-9 at the histone 3 (H3K9ac)-binding...

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Detalles Bibliográficos
Autores principales: Wang, Feng-Sheng, Chen, Yu-Shan, Ko, Jih-Yang, Kuo, Chung-Wen, Ke, Huei-Jing, Hsieh, Chin-Kuei, Wang, Shao-Yu, Kuo, Pei-Chen, Jahr, Holger, Lian, Wei-Shiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349708/
https://www.ncbi.nlm.nih.gov/pubmed/32575577
http://dx.doi.org/10.3390/cells9061500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349708/
https://www.ncbi.nlm.nih.gov/pubmed/32575577
http://dx.doi.org/10.3390/cells9061500

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