HIV Nef and Antiretroviral Therapy Have an Inhibitory Effect on Autophagy in Human Astrocytes that May Contribute to HIV-Associated Neurocognitive Disorders

A significant number of people living with HIV (PLWH) develop HIV-associated neurocognitive disorders (HAND) despite highly effective antiretroviral therapy (ART). Dysregulated macroautophagy (autophagy) is implicated in HAND pathogenesis. The viral protein Nef, expressed even with suppressive ART,...

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Detalles Bibliográficos
Autores principales: Cheney, Laura, Guzik, Hillary, Macaluso, Frank P., Macian, Fernando, Cuervo, Ana Maria, Berman, Joan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349791/
https://www.ncbi.nlm.nih.gov/pubmed/32526847
http://dx.doi.org/10.3390/cells9061426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349791/
https://www.ncbi.nlm.nih.gov/pubmed/32526847
http://dx.doi.org/10.3390/cells9061426

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