CaSR Antagonist (Calcilytic) NPS 2143 Hinders the Release of Neuroinflammatory IL-6, Soluble ICAM-1, RANTES, and MCP-2 from Aβ-Exposed Human Cortical Astrocytes

Available evidence shows that human cortical neurons’ and astrocytes’ calcium-sensing receptors (CaSRs) bind Amyloid-beta (Aβ) oligomers triggering the overproduction/oversecretion of several Alzheimer’s disease (AD) neurotoxins—effects calcilytics suppress. We asked whether Aβ•CaSR signaling might...

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Detalles Bibliográficos
Autores principales: Chiarini, Anna, Armato, Ubaldo, Hu, Peng, Dal Prà, Ilaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349863/
https://www.ncbi.nlm.nih.gov/pubmed/32498476
http://dx.doi.org/10.3390/cells9061386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349863/
https://www.ncbi.nlm.nih.gov/pubmed/32498476
http://dx.doi.org/10.3390/cells9061386

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