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CTLA-4 Blockade, during HIV Virus-Like Particles Immunization, Alters HIV-Specific B-Cell Responses

Studies have shown that blockade of CTLA-4 promoted the expansion of germinal center B-cells in viral infection or immunization with model antigens. Few studies have evaluated the immunological consequences of CTLA-4 blockade during immunization against relevant vaccine candidates. Here, we investig...

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Detalles Bibliográficos
Autores principales: Lewis, Phoebe E., Poteet, Ethan C., Liu, Dongliang, Chen, Changyi, LaBranche, Celia C., Stanfield-Oakley, Sherry A., Montefiori, David C., Ferrari, Guido, Yao, Qizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349993/
https://www.ncbi.nlm.nih.gov/pubmed/32517277
http://dx.doi.org/10.3390/vaccines8020284