Cargando…

GM1 as Adjuvant of Innovative Therapies for Cystic Fibrosis Disease

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is expressed at the apical plasma membrane (PM) of different epithelial cells. The most common mutation responsible for the onset of cystic fibrosis (CF), F508del, inhibits the biosynthesis and transport of the protein at PM, and als...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mancini, Giulia, Loberto, Nicoletta, Olioso, Debora, Dechecchi, Maria Cristina, Cabrini, Giulio, Mauri, Laura, Bassi, Rosaria, Schiumarini, Domitilla, Chiricozzi, Elena, Lippi, Giuseppe, Pesce, Emanuela, Sonnino, Sandro, Pedemonte, Nicoletta, Tamanini, Anna, Aureli, Massimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350007/ https://www.ncbi.nlm.nih.gov/pubmed/32599772 http://dx.doi.org/10.3390/ijms21124486

Ejemplares similares

Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells
por: Schiumarini, Domitilla, et al.
Publicado: (2017)

Sphingolipids and plasma membrane hydrolases in human primary bronchial cells during differentiation and their altered patterns in cystic fibrosis
por: Loberto, Nicoletta, et al.
Publicado: (2020)

Glycohydrolases in the central nervous system: the role of GBA2 in the neuronal differentiation
por: Samarani, Maura, et al.
Publicado: (2015)

Turning the spotlight on the oligosaccharide chain of GM1 ganglioside
por: Chiricozzi, Elena, et al.
Publicado: (2021)

Cross‐talk between CFTR and sphingolipids in cystic fibrosis
por: Dobi, Dorina, et al.
Publicado: (2023)

GM1 Oligosaccharide Efficacy in Parkinson’s Disease: Protection against MPTP
por: Fazzari, Maria, et al.
Publicado: (2023)

GM1 Oligosaccharide Crosses the Human Blood–Brain Barrier In Vitro by a Paracellular Route
por: Di Biase, Erika, et al.
Publicado: (2020)

GBA2-Encoded β-Glucosidase Activity Is Involved in the Inflammatory Response to Pseudomonas aeruginosa
por: Loberto, Nicoletta, et al.
Publicado: (2014)

Massive Accumulation of Sphingomyelin Affects the Lysosomal and Mitochondria Compartments and Promotes Apoptosis in Niemann-Pick Disease Type A
por: Carsana, Emma Veronica, et al.
Publicado: (2022)

miRNAs in Serum Exosomes for Differential Diagnosis of Brain Metastases
por: Catelan, Silvia, et al.
Publicado: (2022)

Biochemical Characterization of the GBA2 c.1780G>C Missense Mutation in Lymphoblastoid Cells from Patients with Spastic Ataxia
por: Malekkou, Anna, et al.
Publicado: (2018)

Novel insights on GM1 and Parkinson's disease: A critical review
por: Fazzari, Maria, et al.
Publicado: (2022)

GM1 Ganglioside Is A Key Factor in Maintaining the Mammalian Neuronal Functions Avoiding Neurodegeneration
por: Chiricozzi, Elena, et al.
Publicado: (2020)

Modulation of calcium signaling depends on the oligosaccharide of GM1 in Neuro2a mouse neuroblastoma cells
por: Lunghi, Giulia, et al.
Publicado: (2020)

Serum Exosomal microRNA-21, 222 and 124-3p as Noninvasive Predictive Biomarkers in Newly Diagnosed High-Grade Gliomas: A Prospective Study
por: Olioso, Debora, et al.
Publicado: (2021)

Parkinson’s disease recovery by GM1 oligosaccharide treatment in the B4galnt1(+/−) mouse model
por: Chiricozzi, Elena, et al.
Publicado: (2019)

Editorial: Special Issue on “Therapeutic Approaches for Cystic Fibrosis”
por: Pedemonte, Nicoletta
Publicado: (2020)

Evaluation of phages and liposomes as combination therapy to counteract Pseudomonas aeruginosa infection in wild-type and CFTR-null models
por: Cafora, Marco, et al.
Publicado: (2022)

Synthesis and Therapeutic Applications of Iminosugars in Cystic Fibrosis
por: Esposito, Anna, et al.
Publicado: (2020)

Distinctive lipid signatures of bronchial epithelial cells associated with cystic fibrosis drugs, including Trikafta
por: Liessi, Nara, et al.
Publicado: (2020)

The relationship between depletion of brain GM1 ganglioside and Parkinson's disease
por: Sonnino, Sandro
Publicado: (2023)

Gangliosides and the Treatment of Neurodegenerative Diseases: A Long Italian Tradition
por: Fazzari, Maria, et al.
Publicado: (2022)

Editorial: Emerging Therapeutic Approaches for Cystic Fibrosis
por: Lopes-Pacheco, Miquéias, et al.
Publicado: (2019)

Proteomics and Metabolomics for Cystic Fibrosis Research
por: Liessi, Nara, et al.
Publicado: (2020)

β-Sitosterol Reduces the Expression of Chemotactic Cytokine Genes in Cystic Fibrosis Bronchial Epithelial Cells
por: Lampronti, Ilaria, et al.
Publicado: (2017)

509 Cystic fibrosis transmembrane conductance regulator positively regulates angiotensin-converting enzyme 2 expression and SARS-CoV-2 viral entry into airway epithelial cells: Implications for patients with cystic fibrosis
por: Bezzerri, V., et al.
Publicado: (2022)

High-Content Screening Identifies Vanilloids as a Novel Class of Inhibitors of NET Formation
por: Sondo, Elvira, et al.
Publicado: (2019)

SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation
por: Bezzerri, Valentino, et al.
Publicado: (2023)

The structure of gangliosides hides a code for determining neuronal functions
por: Lunghi, Giulia, et al.
Publicado: (2021)

Improved Trimethylangelicin Analogs for Cystic Fibrosis: Design, Synthesis and Preliminary Screening
por: Vaccarin, Christian, et al.
Publicado: (2022)

Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators
por: Laselva, Onofrio, et al.
Publicado: (2018)

Enhancing the Expression of CFTR Using Antisense Molecules against MicroRNA miR-145-5p
por: Finotti, Alessia, et al.
Publicado: (2019)

A Peptide-Nucleic Acid Targeting miR-335-5p Enhances Expression of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene with the Possible Involvement of the CFTR Scaffolding Protein NHERF1
por: Tamanini, Anna, et al.
Publicado: (2021)

Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives
por: Brusa, Irene, et al.
Publicado: (2022)

Dual Activity of Aminoarylthiazoles on the Trafficking and Gating Defects of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Caused by Cystic Fibrosis Mutations
por: Pedemonte, Nicoletta, et al.
Publicado: (2011)

A Peptide Nucleic Acid against MicroRNA miR-145-5p Enhances the Expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Calu-3 Cells
por: Fabbri, Enrica, et al.
Publicado: (2017)

β-Glucocerebrosidase Deficiency Activates an Aberrant Lysosome-Plasma Membrane Axis Responsible for the Onset of Neurodegeneration
por: Lunghi, Giulia, et al.
Publicado: (2022)

New TMA (4,6,4′-Trimethyl angelicin) Analogues as Anti-Inflammatory Agents in the Treatment of Cystic Fibrosis Lung Disease
por: Tupini, Chiara, et al.
Publicado: (2022)

Alkali-labile gangliosides
por: Mauri, Laura, et al.
Publicado: (2023)

Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation
por: Tomati, Valeria, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_vlv45mr9lm9ol79tc4jteorvl9