IPSC-Derived Neuronal Cultures Carrying the Alzheimer’s Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network

Genes associated with immune response and inflammation have been identified as genetic risk factors for late-onset Alzheimer´s disease (LOAD). The rare R47H variant within triggering receptor expressed on myeloid cells 2 (TREM2) has been shown to increase the risk for developing Alzheimer’s disease...

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Detalles Bibliográficos
Autores principales: Martins, Soraia, Müller-Schiffmann, Andreas, Erichsen, Lars, Bohndorf, Martina, Wruck, Wasco, Sleegers, Kristel, Van Broeckhoven, Christine, Korth, Carsten, Adjaye, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350255/
https://www.ncbi.nlm.nih.gov/pubmed/32630447
http://dx.doi.org/10.3390/ijms21124516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350255/
https://www.ncbi.nlm.nih.gov/pubmed/32630447
http://dx.doi.org/10.3390/ijms21124516

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