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Tuning GABAergic Inhibition: Gephyrin Molecular Organization and Functions

To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein gephyrin self-assembles to form a scaffold that anchors glycine and GABA(A)Rs to the cytoskeleton, thus ensuring the...

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Detalles Bibliográficos
Autores principales: Pizzarelli, Rocco, Griguoli, Marilena, Zacchi, Paola, Petrini, Enrica Maria, Barberis, Andrea, Cattaneo, Antonino, Cherubini, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351109/
https://www.ncbi.nlm.nih.gov/pubmed/31356900
http://dx.doi.org/10.1016/j.neuroscience.2019.07.036