Cargando…

Methylglyoxal and D-lactate in cisplatin-induced acute kidney injury: Investigation of the potential mechanism via fluorogenic derivatization liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS) proteomic analysis

Nephrotoxicity severely limits the chemotherapeutic efficacy of cisplatin (CDDP). Oxidative stress is associated with CDDP-induced acute kidney injury (AKI). Methylglyoxal (MG) forms advanced glycation end products that elevate oxidative stress. We aimed to explore the role of MG and its metabolite...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Shih-Ming, Chen, Tsung-Hui, Chang, Hui-Ting, Lin, Tzu-Yao, Lin, Chia-Yu, Tsai, Pei-Yun, Imai, Kazuhiro, Chen, Chien-Ming, Lee, Jen-Ai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351171/
https://www.ncbi.nlm.nih.gov/pubmed/32649695
http://dx.doi.org/10.1371/journal.pone.0235849