Bacterial killing by complement requires direct anchoring of membrane attack complex precursor C5b-7

An important effector function of the human complement system is to directly kill Gram-negative bacteria via Membrane Attack Complex (MAC) pores. MAC pores are assembled when surface-bound convertase enzymes convert C5 into C5b, which together with C6, C7, C8 and multiple copies of C9 forms a transm...

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Detalles Bibliográficos
Autores principales: Doorduijn, Dennis J., Bardoel, Bart W., Heesterbeek, Dani A. C., Ruyken, Maartje, Benn, Georgina, Parsons, Edward S., Hoogenboom, Bart W., Rooijakkers, Suzan H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351214/
https://www.ncbi.nlm.nih.gov/pubmed/32569291
http://dx.doi.org/10.1371/journal.ppat.1008606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351214/
https://www.ncbi.nlm.nih.gov/pubmed/32569291
http://dx.doi.org/10.1371/journal.ppat.1008606

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