CARD14(E138A) signalling in keratinocytes induces TNF-dependent skin and systemic inflammation

To investigate how the CARD14(E138A) psoriasis-associated mutation induces skin inflammation, a knock-in mouse strain was generated that allows tamoxifen-induced expression of the homologous Card14(E138A) mutation from the endogenous mouse Card14 locus. Heterozygous expression of CARD14(E138A) rapid...

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Detalles Bibliográficos
Autores principales: Manils, Joan, Webb, Louise V, Howes, Ashleigh, Janzen, Julia, Boeing, Stefan, Bowcock, Anne M, Ley, Steven C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351492/
https://www.ncbi.nlm.nih.gov/pubmed/32597759
http://dx.doi.org/10.7554/eLife.56720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351492/
https://www.ncbi.nlm.nih.gov/pubmed/32597759
http://dx.doi.org/10.7554/eLife.56720

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