Structure-based designing efficient peptides based on p53 binding site residues to disrupt p53-MDM2/X interaction

MDM2 and MDMX are known as overexpressed oncoproteins in several wild-type p53 cancer cells. The development of potent and dual antagonist peptides for p53-MDM2/X is a continuous challenge. In this study, we intended to investigate the pivotal structural points respecting the development of potent a...

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Detalles Bibliográficos
Autores principales: Rasafar, Nasim, Barzegar, Abolfazl, Mehdizadeh Aghdam, Elnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351717/
https://www.ncbi.nlm.nih.gov/pubmed/32651397
http://dx.doi.org/10.1038/s41598-020-67510-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351717/
https://www.ncbi.nlm.nih.gov/pubmed/32651397
http://dx.doi.org/10.1038/s41598-020-67510-8

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