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Structure-based designing efficient peptides based on p53 binding site residues to disrupt p53-MDM2/X interaction
MDM2 and MDMX are known as overexpressed oncoproteins in several wild-type p53 cancer cells. The development of potent and dual antagonist peptides for p53-MDM2/X is a continuous challenge. In this study, we intended to investigate the pivotal structural points respecting the development of potent a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351717/ https://www.ncbi.nlm.nih.gov/pubmed/32651397 http://dx.doi.org/10.1038/s41598-020-67510-8 |