Structural basis of seamless excision and specific targeting by piggyBac transposase

The piggyBac DNA transposon is used widely in genome engineering applications. Unlike other transposons, its excision site can be precisely repaired without leaving footprints and it integrates specifically at TTAA tetranucleotides. We present cryo-EM structures of piggyBac transpososomes: a synapti...

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Detalles Bibliográficos
Autores principales: Chen, Qiujia, Luo, Wentian, Veach, Ruth Ann, Hickman, Alison B., Wilson, Matthew H., Dyda, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351741/
https://www.ncbi.nlm.nih.gov/pubmed/32651359
http://dx.doi.org/10.1038/s41467-020-17128-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351741/
https://www.ncbi.nlm.nih.gov/pubmed/32651359
http://dx.doi.org/10.1038/s41467-020-17128-1

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