HDAC8 Inhibition Reduces Lesional Iba-1+ Cell Infiltration after Spinal Cord Injury without Effects on Functional Recovery

Pan-histone deacetylase (HDAC) inhibition with valproic acid (VPA) has beneficial effects after spinal cord injury (SCI), although with side effects. We focused on specific HDAC8 inhibition, because it is known to reduce anti-inflammatory mediators produced by macrophages (Mφ). We hypothesized that...

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Detalles Bibliográficos
Autores principales: Hendrix, Sven, Sanchez, Selien, Ventriglia, Elissia, Lemmens, Stefanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352158/
https://www.ncbi.nlm.nih.gov/pubmed/32630606
http://dx.doi.org/10.3390/ijms21124539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352158/
https://www.ncbi.nlm.nih.gov/pubmed/32630606
http://dx.doi.org/10.3390/ijms21124539

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