Restoration of MHC-I on Tumor Cells by Fhit Transfection Promotes Immune Rejection and Acts as an Individualized Immunotherapeutic Vaccine

The capacity of cytotoxic-T lymphocytes to recognize and destroy tumor cells depends on the surface expression by tumor cells of MHC class I molecules loaded with tumor antigen peptides. Loss of MHC-I expression is the most frequent mechanism by which tumor cells evade the immune response. The resto...

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Detalles Bibliográficos
Autores principales: Pulido, María, Chamorro, Virginia, Romero, Irene, Algarra, Ignacio, S-Montalvo, Alba, Collado, Antonia, Garrido, Federico, Garcia-Lora, Angel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352176/
https://www.ncbi.nlm.nih.gov/pubmed/32545680
http://dx.doi.org/10.3390/cancers12061563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352176/
https://www.ncbi.nlm.nih.gov/pubmed/32545680
http://dx.doi.org/10.3390/cancers12061563

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