Functional Characterization of POFUT1 Variants Associated with Colorectal Cancer

Background: Protein O-fucosyltransferase 1 (POFUT1) overexpression, which is observed in many cancers such as colorectal cancer (CRC), leads to a NOTCH signaling dysregulation associated with the tumoral process. In rare CRC cases, with no POFUT1 overexpression, seven missense mutations were found i...

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Detalles Bibliográficos
Autores principales: Deschuyter, Marlène, Pennarubia, Florian, Pinault, Emilie, Legardinier, Sébastien, Maftah, Abderrahman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352195/
https://www.ncbi.nlm.nih.gov/pubmed/32486426
http://dx.doi.org/10.3390/cancers12061430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352195/
https://www.ncbi.nlm.nih.gov/pubmed/32486426
http://dx.doi.org/10.3390/cancers12061430

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