Cargando…

A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells

There is currently no effective long-term treatment for ovarian cancer (OC) resistant to poly-chemotherapy regimens based on platinum drugs. Preclinical and clinical studies have demonstrated a strong association between development of Pt-drug resistance and increased thymidylate synthase (hTS) expr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marverti, Gaetano, Gozzi, Gaia, Maretti, Eleonora, Lauriola, Angela, Severi, Leda, Sacchetti, Francesca, Losi, Lorena, Pacifico, Salvatore, Ferrari, Stefania, Ponterini, Glauco, Leo, Eliana, Costi, Maria Paola, D’Arca, Domenico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352236/ https://www.ncbi.nlm.nih.gov/pubmed/32585842 http://dx.doi.org/10.3390/ijms21124452

Ejemplares similares

Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology
por: Ponterini, Glauco, et al.
Publicado: (2016)

Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations
por: Pozzi, Cecilia, et al.
Publicado: (2021)

Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth
por: Pacifico, Salvatore, et al.
Publicado: (2019)

Folic Acid–Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting
por: Marverti, Gaetano, et al.
Publicado: (2021)

The 1,10-Phenanthroline Ligand Enhances the Antiproliferative Activity of DNA-Intercalating Thiourea-Pd(II) and -Pt(II) Complexes Against Cisplatin-Sensitive and -Resistant Human Ovarian Cancer Cell Lines
por: Marverti, Gaetano, et al.
Publicado: (2019)

Translational repression of thymidylate synthase by targeting its mRNA
por: Garg, Divita, et al.
Publicado: (2013)

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth
por: Costantino, Luca, et al.
Publicado: (2022)

Proteomic and Bioinformatic Studies for the Characterization of Response to Pemetrexed in Platinum Drug Resistant Ovarian Cancer
por: Severi, Leda, et al.
Publicado: (2018)

Involvement of epigenetic modification of TERT promoter in response to all-trans retinoic acid in ovarian cancer cell lines
por: Losi, Lorena, et al.
Publicado: (2019)

Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library
por: Lauriola, Angela, et al.
Publicado: (2022)

Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies
por: Davalli, Pierpaola, et al.
Publicado: (2018)

Repurposing of Drugs Targeting YAP-TEAD Functions
por: Elisi, Gian Marco, et al.
Publicado: (2018)

Telomere Dysfunction Is Associated with Altered DNA Organization in Trichoplein/Tchp/Mitostatin (TpMs) Depleted Cells
por: Lauriola, Angela, et al.
Publicado: (2022)

Targeting the Interplay of Independent Cellular Pathways and Immunity: A Challenge in Cancer Immunotherapy
por: Lauriola, Angela, et al.
Publicado: (2023)

Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma
por: D’Arca, Domenico, et al.
Publicado: (2023)

Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells
por: Lauriola, Angela, et al.
Publicado: (2020)

Transcriptional Activation and Cell Cycle Block Are the Keys for 5-Fluorouracil Induced Up-Regulation of Human Thymidylate Synthase Expression
por: Ligabue, Alessio, et al.
Publicado: (2012)

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases
por: Davalli, Pierpaola, et al.
Publicado: (2016)

Fluorescence Observables and Enzyme Kinetics in the Investigation of PPI Modulation by Small Molecules: Detection, Mechanistic Insight, and Functional Consequences
por: Ponterini, Glauco
Publicado: (2013)

Conventional and PEGylated Liposomes as Vehicles of Copaifera sabulicola
por: Blanco, Ian M. R., et al.
Publicado: (2023)

PEGylated liposomes: immunological responses
por: Mohamed, Marwa, et al.
Publicado: (2019)

Liposomal Formulations to Modulate the Tumour Microenvironment and Antitumour Immune Response
por: Gilabert-Oriol, Roger, et al.
Publicado: (2018)

Pegylated liposomal doxorubicin in ovarian cancer
por: Green, Andrew E, et al.
Publicado: (2006)

Pegylated liposomal doxorubicin in ovarian cancer
por: Strother, Robert, et al.
Publicado: (2009)

Pegylated liposomal doxorubicin for myeloid neoplasms
por: Zhang, Cheng, et al.
Publicado: (2019)

Evidence of Protein Adsorption in Pegylated Liposomes: Influence of Liposomal Decoration
por: Sangrà, Marc, et al.
Publicado: (2017)

Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors
por: Kobayashi, Hiroyuki, et al.
Publicado: (1995)

In vitro antitumour activity of cis- and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils; effects on thymidylate synthesis.
por: van der Wilt, C. L., et al.
Publicado: (1993)

Efficacy of Liposomal Monensin on the Enhancement of the Antitumour Activity of Liposomal Ricin in Human Epidermoid Carcinoma (KB) Cells
por: Tyagi, N., et al.
Publicado: (2013)

Pegylated liposomal doxorubicin in the management of ovarian cancer
por: Ferrandina, Gabriella, et al.
Publicado: (2010)

A tale of the two PEGylated liposomal doxorubicins
por: Chou, Hunghsueh, et al.
Publicado: (2015)

Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes
por: Miatmoko, Andang, et al.
Publicado: (2021)

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence
por: Jagielska, Elżbieta, et al.
Publicado: (2014)

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R
por: Pozzi, Cecilia, et al.
Publicado: (2019)

Conservation and Role of Electrostatics in Thymidylate Synthase
por: Garg, Divita, et al.
Publicado: (2015)

Pegylated Liposomal Doxorubicin-induced Palmar-plantar Erythrodysesthesia
por: Moreira-Barros, Joana, et al.
Publicado: (2018)

Prolonged use of pegylated liposomal doxorubicin in gynecologic malignancies
por: Yost, S., et al.
Publicado: (2019)

Pegylated liposomal doxorubicin in patients with epithelial ovarian cancer
por: Yuan, Zhen, et al.
Publicado: (2021)

Impact of PEGylated Liposomal Doxorubicin and Carboplatin Combination on Glioblastoma
por: Ghaferi, Mohsen, et al.
Publicado: (2022)

The Impact of Nanobody Density on the Targeting Efficiency of PEGylated Liposomes
por: Mesquita, Bárbara S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_iut9v63i5nrqdn9jkaei3t2f6h