Cargando…
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells
There is currently no effective long-term treatment for ovarian cancer (OC) resistant to poly-chemotherapy regimens based on platinum drugs. Preclinical and clinical studies have demonstrated a strong association between development of Pt-drug resistance and increased thymidylate synthase (hTS) expr...
Autores principales: | Marverti, Gaetano, Gozzi, Gaia, Maretti, Eleonora, Lauriola, Angela, Severi, Leda, Sacchetti, Francesca, Losi, Lorena, Pacifico, Salvatore, Ferrari, Stefania, Ponterini, Glauco, Leo, Eliana, Costi, Maria Paola, D’Arca, Domenico |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352236/ https://www.ncbi.nlm.nih.gov/pubmed/32585842 http://dx.doi.org/10.3390/ijms21124452 |
Ejemplares similares
-
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology
por: Ponterini, Glauco, et al.
Publicado: (2016) -
Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations
por: Pozzi, Cecilia, et al.
Publicado: (2021) -
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth
por: Pacifico, Salvatore, et al.
Publicado: (2019) -
Folic Acid–Peptide
Conjugates Combine Selective
Cancer Cell Internalization with Thymidylate Synthase Dimer Interface
Targeting
por: Marverti, Gaetano, et al.
Publicado: (2021) -
The 1,10-Phenanthroline Ligand Enhances the Antiproliferative Activity of DNA-Intercalating Thiourea-Pd(II) and -Pt(II) Complexes Against Cisplatin-Sensitive and -Resistant Human Ovarian Cancer Cell Lines
por: Marverti, Gaetano, et al.
Publicado: (2019)