Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant Braf(V600E) Melanoma

Melanoma patients harboring the BRAF(V600E) mutation are treated with vemurafenib. Almost all of them ultimately acquire resistance, leading to disease progression. Here, we find that a small molecule from a marine sponge, panicein A hydroquinone (PAH), overcomes resistance of BRAF(V600E) melanoma c...

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Detalles Bibliográficos
Autores principales: Signetti, Laurie, Elizarov, Nelli, Simsir, Méliné, Paquet, Agnès, Douguet, Dominique, Labbal, Fabien, Debayle, Delphine, Di Giorgio, Audrey, Biou, Valérie, Girard, Christophe, Duca, Maria, Bretillon, Lionel, Bertolotto, Corine, Verrier, Bernard, Azoulay, Stéphane, Mus-Veteau, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352342/
https://www.ncbi.nlm.nih.gov/pubmed/32526884
http://dx.doi.org/10.3390/cancers12061500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352342/
https://www.ncbi.nlm.nih.gov/pubmed/32526884
http://dx.doi.org/10.3390/cancers12061500

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