The CXCR4 Antagonist, AMD3100, Reverses Mesenchymal Stem Cell-Mediated Drug Resistance in Relapsed/Refractory Acute Lymphoblastic Leukemia

PURPOSE: To investigate the role of the CXCR4/CXCL12 axis in chemotherapy resistance in refractory/relapsed (R/R) ALL patients. METHODS: CXCR4 expression on ALL cells from newly diagnosed or R/R ALL patients were detected using flow cytometry. The CXCR4/CXCL12 signaling pathway was blocked by the CX...

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Detalles Bibliográficos
Autores principales: Wang, Shan, Wang, Xiaojiao, Liu, Sha, Zhang, Shengnan, Wei, Xudong, Song, Yongping, Yin, Qingsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352451/
https://www.ncbi.nlm.nih.gov/pubmed/32753894
http://dx.doi.org/10.2147/OTT.S249425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352451/
https://www.ncbi.nlm.nih.gov/pubmed/32753894
http://dx.doi.org/10.2147/OTT.S249425

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