Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds

BRAF inhibitors can delay the progression of metastatic melanoma, but resistance usually emerges, leading to relapse. Drugs simultaneously targeting two or more pathways essential for cancer growth could slow or prevent the development of resistant clones. Here, we identified pyridinyl imidazole com...

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Detalles Bibliográficos
Autores principales: Palušová, Veronika, Renzová, Tereza, Verlande, Amandine, Vaclová, Tereza, Medková, Michaela, Cetlová, Linda, Sedláčková, Miroslava, Hříbková, Hana, Slaninová, Iva, Krutá, Miriama, Rotrekl, Vladimír, Uhlířová, Hana, Křížová, Aneta, Chmelík, Radim, Veselý, Pavel, Krafčíková, Michaela, Trantírek, Lukáš, Schink, Kay Oliver, Uldrijan, Stjepan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352453/
https://www.ncbi.nlm.nih.gov/pubmed/32531927
http://dx.doi.org/10.3390/cancers12061516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352453/
https://www.ncbi.nlm.nih.gov/pubmed/32531927
http://dx.doi.org/10.3390/cancers12061516

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