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Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study

There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complicat...

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Autores principales: Abuín-Fernández, Jose, Tapia-Guerrero, María José, López-Urdiales, Rafael, Herranz-Antolín, Sandra, García-Almeida, Jose Manuel, García-Malpartida, Katherine, Ferrer-Gómez, Mercedes, Cancer-Minchot, Emilia, Luengo-Pérez, Luis Miguel, Álvarez-Hernández, Julia, Aragón Valera, Carmen, Ocón-Bretón, Julia, García-Manzanares, Álvaro, Bretón-Lesmes, Irene, Serrano-Aguayo, Pilar, Pérez-Ferre, Natalia, López-Gómez, Juan José, Olivares-Alcolea, Josefina, Arraiza-Irigoyen, Carmen, Tejera-Pérez, Cristina, Martínez-González, Jorge Daniel, Urioste-Fondo, Ana, Abad-González, Ángel Luis, Molina-Puerta, María José, Zugasti-Murillo, Ana, Parra-Barona, Juan, López-Cobo, Irela, Olveira, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352525/
https://www.ncbi.nlm.nih.gov/pubmed/32471262
http://dx.doi.org/10.3390/nu12061566
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author Abuín-Fernández, Jose
Tapia-Guerrero, María José
López-Urdiales, Rafael
Herranz-Antolín, Sandra
García-Almeida, Jose Manuel
García-Malpartida, Katherine
Ferrer-Gómez, Mercedes
Cancer-Minchot, Emilia
Luengo-Pérez, Luis Miguel
Álvarez-Hernández, Julia
Aragón Valera, Carmen
Ocón-Bretón, Julia
García-Manzanares, Álvaro
Bretón-Lesmes, Irene
Serrano-Aguayo, Pilar
Pérez-Ferre, Natalia
López-Gómez, Juan José
Olivares-Alcolea, Josefina
Arraiza-Irigoyen, Carmen
Tejera-Pérez, Cristina
Martínez-González, Jorge Daniel
Urioste-Fondo, Ana
Abad-González, Ángel Luis
Molina-Puerta, María José
Zugasti-Murillo, Ana
Parra-Barona, Juan
López-Cobo, Irela
Olveira, Gabriel
author_facet Abuín-Fernández, Jose
Tapia-Guerrero, María José
López-Urdiales, Rafael
Herranz-Antolín, Sandra
García-Almeida, Jose Manuel
García-Malpartida, Katherine
Ferrer-Gómez, Mercedes
Cancer-Minchot, Emilia
Luengo-Pérez, Luis Miguel
Álvarez-Hernández, Julia
Aragón Valera, Carmen
Ocón-Bretón, Julia
García-Manzanares, Álvaro
Bretón-Lesmes, Irene
Serrano-Aguayo, Pilar
Pérez-Ferre, Natalia
López-Gómez, Juan José
Olivares-Alcolea, Josefina
Arraiza-Irigoyen, Carmen
Tejera-Pérez, Cristina
Martínez-González, Jorge Daniel
Urioste-Fondo, Ana
Abad-González, Ángel Luis
Molina-Puerta, María José
Zugasti-Murillo, Ana
Parra-Barona, Juan
López-Cobo, Irela
Olveira, Gabriel
author_sort Abuín-Fernández, Jose
collection PubMed
description There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality.
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spelling pubmed-73525252020-07-15 Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study Abuín-Fernández, Jose Tapia-Guerrero, María José López-Urdiales, Rafael Herranz-Antolín, Sandra García-Almeida, Jose Manuel García-Malpartida, Katherine Ferrer-Gómez, Mercedes Cancer-Minchot, Emilia Luengo-Pérez, Luis Miguel Álvarez-Hernández, Julia Aragón Valera, Carmen Ocón-Bretón, Julia García-Manzanares, Álvaro Bretón-Lesmes, Irene Serrano-Aguayo, Pilar Pérez-Ferre, Natalia López-Gómez, Juan José Olivares-Alcolea, Josefina Arraiza-Irigoyen, Carmen Tejera-Pérez, Cristina Martínez-González, Jorge Daniel Urioste-Fondo, Ana Abad-González, Ángel Luis Molina-Puerta, María José Zugasti-Murillo, Ana Parra-Barona, Juan López-Cobo, Irela Olveira, Gabriel Nutrients Article There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality. MDPI 2020-05-27 /pmc/articles/PMC7352525/ /pubmed/32471262 http://dx.doi.org/10.3390/nu12061566 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abuín-Fernández, Jose
Tapia-Guerrero, María José
López-Urdiales, Rafael
Herranz-Antolín, Sandra
García-Almeida, Jose Manuel
García-Malpartida, Katherine
Ferrer-Gómez, Mercedes
Cancer-Minchot, Emilia
Luengo-Pérez, Luis Miguel
Álvarez-Hernández, Julia
Aragón Valera, Carmen
Ocón-Bretón, Julia
García-Manzanares, Álvaro
Bretón-Lesmes, Irene
Serrano-Aguayo, Pilar
Pérez-Ferre, Natalia
López-Gómez, Juan José
Olivares-Alcolea, Josefina
Arraiza-Irigoyen, Carmen
Tejera-Pérez, Cristina
Martínez-González, Jorge Daniel
Urioste-Fondo, Ana
Abad-González, Ángel Luis
Molina-Puerta, María José
Zugasti-Murillo, Ana
Parra-Barona, Juan
López-Cobo, Irela
Olveira, Gabriel
Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
title Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
title_full Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
title_fullStr Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
title_full_unstemmed Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
title_short Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
title_sort fish oil enriched intravenous lipid emulsions reduce triglyceride levels in non-critically ill patients with tpn and type 2 diabetes. a post-hoc analysis of the insupar study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352525/
https://www.ncbi.nlm.nih.gov/pubmed/32471262
http://dx.doi.org/10.3390/nu12061566
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