Cargando…
Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy
The sialic acid-based molecular mimicry in pathogens and malignant cells is a regulatory mechanism that leads to cross-reactivity with host antigens resulting in suppression and tolerance in the immune system. The interplay between sialoglycans and immunoregulatory Siglec receptors promotes foreign...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352527/ https://www.ncbi.nlm.nih.gov/pubmed/32575400 http://dx.doi.org/10.3390/ijms21124361 |
_version_ | 1783557658832273408 |
---|---|
author | Wielgat, Przemyslaw Rogowski, Karol Niemirowicz-Laskowska, Katarzyna Car, Halina |
author_facet | Wielgat, Przemyslaw Rogowski, Karol Niemirowicz-Laskowska, Katarzyna Car, Halina |
author_sort | Wielgat, Przemyslaw |
collection | PubMed |
description | The sialic acid-based molecular mimicry in pathogens and malignant cells is a regulatory mechanism that leads to cross-reactivity with host antigens resulting in suppression and tolerance in the immune system. The interplay between sialoglycans and immunoregulatory Siglec receptors promotes foreign antigens hiding and immunosurveillance impairment. Therefore, molecular targeting of immune checkpoints, including sialic acid-Siglec axis, is a promising new field of inflammatory disorders and cancer therapy. However, the conventional drugs used in regular management can interfere with glycome machinery and exert a divergent effect on immune controlling systems. Here, we focus on the known effects of standard therapies on the sialoglycan-Siglec checkpoint and their importance in diagnosis, prediction, and clinical outcomes. |
format | Online Article Text |
id | pubmed-7352527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73525272020-07-15 Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy Wielgat, Przemyslaw Rogowski, Karol Niemirowicz-Laskowska, Katarzyna Car, Halina Int J Mol Sci Review The sialic acid-based molecular mimicry in pathogens and malignant cells is a regulatory mechanism that leads to cross-reactivity with host antigens resulting in suppression and tolerance in the immune system. The interplay between sialoglycans and immunoregulatory Siglec receptors promotes foreign antigens hiding and immunosurveillance impairment. Therefore, molecular targeting of immune checkpoints, including sialic acid-Siglec axis, is a promising new field of inflammatory disorders and cancer therapy. However, the conventional drugs used in regular management can interfere with glycome machinery and exert a divergent effect on immune controlling systems. Here, we focus on the known effects of standard therapies on the sialoglycan-Siglec checkpoint and their importance in diagnosis, prediction, and clinical outcomes. MDPI 2020-06-19 /pmc/articles/PMC7352527/ /pubmed/32575400 http://dx.doi.org/10.3390/ijms21124361 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wielgat, Przemyslaw Rogowski, Karol Niemirowicz-Laskowska, Katarzyna Car, Halina Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy |
title | Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy |
title_full | Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy |
title_fullStr | Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy |
title_full_unstemmed | Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy |
title_short | Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy |
title_sort | sialic acid-siglec axis as molecular checkpoints targeting of immune system: smart players in pathology and conventional therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352527/ https://www.ncbi.nlm.nih.gov/pubmed/32575400 http://dx.doi.org/10.3390/ijms21124361 |
work_keys_str_mv | AT wielgatprzemyslaw sialicacidsiglecaxisasmolecularcheckpointstargetingofimmunesystemsmartplayersinpathologyandconventionaltherapy AT rogowskikarol sialicacidsiglecaxisasmolecularcheckpointstargetingofimmunesystemsmartplayersinpathologyandconventionaltherapy AT niemirowiczlaskowskakatarzyna sialicacidsiglecaxisasmolecularcheckpointstargetingofimmunesystemsmartplayersinpathologyandconventionaltherapy AT carhalina sialicacidsiglecaxisasmolecularcheckpointstargetingofimmunesystemsmartplayersinpathologyandconventionaltherapy |