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Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy

The sialic acid-based molecular mimicry in pathogens and malignant cells is a regulatory mechanism that leads to cross-reactivity with host antigens resulting in suppression and tolerance in the immune system. The interplay between sialoglycans and immunoregulatory Siglec receptors promotes foreign...

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Autores principales: Wielgat, Przemyslaw, Rogowski, Karol, Niemirowicz-Laskowska, Katarzyna, Car, Halina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352527/
https://www.ncbi.nlm.nih.gov/pubmed/32575400
http://dx.doi.org/10.3390/ijms21124361
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author Wielgat, Przemyslaw
Rogowski, Karol
Niemirowicz-Laskowska, Katarzyna
Car, Halina
author_facet Wielgat, Przemyslaw
Rogowski, Karol
Niemirowicz-Laskowska, Katarzyna
Car, Halina
author_sort Wielgat, Przemyslaw
collection PubMed
description The sialic acid-based molecular mimicry in pathogens and malignant cells is a regulatory mechanism that leads to cross-reactivity with host antigens resulting in suppression and tolerance in the immune system. The interplay between sialoglycans and immunoregulatory Siglec receptors promotes foreign antigens hiding and immunosurveillance impairment. Therefore, molecular targeting of immune checkpoints, including sialic acid-Siglec axis, is a promising new field of inflammatory disorders and cancer therapy. However, the conventional drugs used in regular management can interfere with glycome machinery and exert a divergent effect on immune controlling systems. Here, we focus on the known effects of standard therapies on the sialoglycan-Siglec checkpoint and their importance in diagnosis, prediction, and clinical outcomes.
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spelling pubmed-73525272020-07-15 Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy Wielgat, Przemyslaw Rogowski, Karol Niemirowicz-Laskowska, Katarzyna Car, Halina Int J Mol Sci Review The sialic acid-based molecular mimicry in pathogens and malignant cells is a regulatory mechanism that leads to cross-reactivity with host antigens resulting in suppression and tolerance in the immune system. The interplay between sialoglycans and immunoregulatory Siglec receptors promotes foreign antigens hiding and immunosurveillance impairment. Therefore, molecular targeting of immune checkpoints, including sialic acid-Siglec axis, is a promising new field of inflammatory disorders and cancer therapy. However, the conventional drugs used in regular management can interfere with glycome machinery and exert a divergent effect on immune controlling systems. Here, we focus on the known effects of standard therapies on the sialoglycan-Siglec checkpoint and their importance in diagnosis, prediction, and clinical outcomes. MDPI 2020-06-19 /pmc/articles/PMC7352527/ /pubmed/32575400 http://dx.doi.org/10.3390/ijms21124361 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wielgat, Przemyslaw
Rogowski, Karol
Niemirowicz-Laskowska, Katarzyna
Car, Halina
Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy
title Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy
title_full Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy
title_fullStr Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy
title_full_unstemmed Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy
title_short Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy
title_sort sialic acid-siglec axis as molecular checkpoints targeting of immune system: smart players in pathology and conventional therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352527/
https://www.ncbi.nlm.nih.gov/pubmed/32575400
http://dx.doi.org/10.3390/ijms21124361
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