Genetic Target Modulation Employing CRISPR/Cas9 Identifies Glyoxalase 1 as a Novel Molecular Determinant of Invasion and Metastasis in A375 Human Malignant Melanoma Cells In Vitro and In Vivo

Metabolic reprogramming is a molecular hallmark of cancer. Recently, we have reported the overexpression of glyoxalase 1 (encoded by GLO1), a glutathione-dependent enzyme involved in detoxification of the reactive glycolytic byproduct methylglyoxal, in human malignant melanoma cell culture models an...

Descripción completa

Detalles Bibliográficos
Autores principales: Jandova, Jana, Perer, Jessica, Hua, Anh, Snell, Jeremy A., Wondrak, Georg T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352620/
https://www.ncbi.nlm.nih.gov/pubmed/32466621
http://dx.doi.org/10.3390/cancers12061369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352620/
https://www.ncbi.nlm.nih.gov/pubmed/32466621
http://dx.doi.org/10.3390/cancers12061369

Ejemplares similares