CRISPR-Mediated Non-Viral Site-Specific Gene Integration and Expression in T Cells: Protocol and Application for T-Cell Therapy

T cells engineered with chimeric antigen receptors (CARs) show great promise in the treatment of some cancers. Modifying T cells to express CARs generally relies on T-cell transduction using viral vectors carrying a transgene, resulting in semi-random DNA integration within the T-cell genome. While...

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Detalles Bibliográficos
Autores principales: Odé, Zelda, Condori, Jose, Peterson, Nicolas, Zhou, Sheng, Krenciute, Giedre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352666/
https://www.ncbi.nlm.nih.gov/pubmed/32604839
http://dx.doi.org/10.3390/cancers12061704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352666/
https://www.ncbi.nlm.nih.gov/pubmed/32604839
http://dx.doi.org/10.3390/cancers12061704

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