The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer

Lung adenocarcinoma cells express high levels of ALDH1L1, an enzyme of the one-carbon pathway that catalyzes the conversion of 10-formyltetrahydrofolate into tetrahydrofolate and NAD(P)H. In this study, we evaluated the potential of ALDH1L1 as a therapeutic target by deleting the Aldh1l1 gene in Kra...

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Detalles Bibliográficos
Autores principales: Lee, Seon-Hyeong, Jeon, Yoon, Kang, Joon Hee, Jang, Hyonchol, Lee, Ho, Kim, Soo-Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352727/
https://www.ncbi.nlm.nih.gov/pubmed/32481524
http://dx.doi.org/10.3390/cancers12061382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352727/
https://www.ncbi.nlm.nih.gov/pubmed/32481524
http://dx.doi.org/10.3390/cancers12061382

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