Cargando…

The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer

Lung adenocarcinoma cells express high levels of ALDH1L1, an enzyme of the one-carbon pathway that catalyzes the conversion of 10-formyltetrahydrofolate into tetrahydrofolate and NAD(P)H. In this study, we evaluated the potential of ALDH1L1 as a therapeutic target by deleting the Aldh1l1 gene in Kra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Seon-Hyeong, Jeon, Yoon, Kang, Joon Hee, Jang, Hyonchol, Lee, Ho, Kim, Soo-Youl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352727/ https://www.ncbi.nlm.nih.gov/pubmed/32481524 http://dx.doi.org/10.3390/cancers12061382

Ejemplares similares

Reply to Krupenko et al., Comment on “Lee et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer Cancers 2020, 12, 1382”
por: Lee, Seon-Hyeong, et al.
Publicado: (2021)

Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion
por: Kang, Joon Hee, et al.
Publicado: (2016)

Is ALDH1L1 Elevated in Lung Cancer? Comment on: Lee, S.-H.; et al. “The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer” Cancers 2020, 12, 1382
por: Krupenko, Sergey A., et al.
Publicado: (2021)

Overall survival of pancreatic ductal adenocarcinoma is doubled by Aldh7a1 deletion in the KPC mouse
por: Lee, Jae-Seon, et al.
Publicado: (2021)

Phenformin enhances the therapeutic effect of selumetinib in KRAS-mutant non-small cell lung cancer irrespective of LKB1 status
por: Zhang, Jun, et al.
Publicado: (2017)

Oxoglutarate Carrier Inhibition Reduced Melanoma Growth and Invasion by Reducing ATP Production
por: Lee, Jae-Seon, et al.
Publicado: (2020)

Synergistic Anti-Cancer Effect of Phenformin and Oxamate
por: Miskimins, W. Keith, et al.
Publicado: (2014)

Blockade of P-Glycoprotein Decreased the Disposition of Phenformin and Increased Plasma Lactate Level
por: Choi, Min-Koo, et al.
Publicado: (2016)

Targeting Oxidative Phosphorylation Reverses Drug Resistance in Cancer Cells by Blocking Autophagy Recycling
por: Lee, Jae-Seon, et al.
Publicado: (2020)

Phenformin as an Anticancer Agent: Challenges and Prospects
por: García Rubiño, Mª Eugenia, et al.
Publicado: (2019)

ATP Production Relies on Fatty Acid Oxidation Rather than Glycolysis in Pancreatic Ductal Adenocarcinoma
por: Lee, Jae-Seon, et al.
Publicado: (2020)

Phenformin as prophylaxis and therapy in breast cancer xenografts
por: Appleyard, M V C L, et al.
Publicado: (2012)

A Comparative Study of the Lipophilicity of Metformin and Phenformin
por: Dołowy, Małgorzata, et al.
Publicado: (2021)

Effects of metformin and phenformin on apoptosis and epithelial‐mesenchymal transition in chemoresistant rectal cancer
por: Park, Ji‐Hye, et al.
Publicado: (2019)

Aldehyde dehydrogenase is used by cancer cells for energy metabolism
por: Kang, Joon Hee, et al.
Publicado: (2016)

Destabilization of MYC/MYCN by the mitochondrial inhibitors, metaiodobenzylguanidine, metformin and phenformin
por: WANG, STEPHANIE S., et al.
Publicado: (2014)

Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma
por: Jiang, Wei, et al.
Publicado: (2016)

The antitumor properties of metformin and phenformin reflect their ability to inhibit the actions of differentiated embryo chondrocyte 1
por: Kuo, Chun-Lin, et al.
Publicado: (2019)

Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation
por: Lee, Jae-Seon, et al.
Publicado: (2019)

Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation
por: Lee, Jae-Seon, et al.
Publicado: (2019)

Loss of Rb1 Enhances Glycolytic Metabolism in Kras-Driven Lung Tumors In Vivo
por: Conroy, Lindsey R., et al.
Publicado: (2020)

Activated cMET and IGF1R-Driven PI3K Signaling Predicts Poor Survival in Colorectal Cancers Independent of KRAS Mutational Status
por: Lee, Jeeyun, et al.
Publicado: (2014)

Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis
por: Romero, Rodrigo, et al.
Publicado: (2017)

Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancer
por: Weng, Ching-Chieh, et al.
Publicado: (2019)

Nf1 loss promotes Kras‐driven lung adenocarcinoma and results in Psat1‐mediated glutamate dependence
por: Wang, Xiaojing, et al.
Publicado: (2019)

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
por: Totten, Stephanie P., et al.
Publicado: (2021)

Therapeutic potential of the metabolic modulator phenformin in targeting the stem cell compartment in melanoma
por: Petrachi, Tiziana, et al.
Publicado: (2016)

The anti-cancer effects of phenformin in thyroid cancer cell lines and in normal thyrocytes
por: Coperchini, Francesca, et al.
Publicado: (2019)

PGC1α Loss Promotes Lung Cancer Metastasis through Epithelial-Mesenchymal Transition
por: Oh, Taek-In, et al.
Publicado: (2021)

Complex Behavior of ALDH1A1 and IGFBP1 in Liver Metastasis from a Colorectal Cancer
por: Kim, Jin Cheon, et al.
Publicado: (2016)

Transglutaminase 2 Promotes Autophagy by LC3 Induction through p53 Depletion in Cancer Cell
por: Kang, Joon Hee, et al.
Publicado: (2019)

Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells
por: Liu, Xinwei, et al.
Publicado: (2016)

Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1α-p300 Binding in Renal Cell Carcinoma
por: Lee, Seon-Hyeong, et al.
Publicado: (2020)

Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC
por: Lee, Jae-Seon, et al.
Publicado: (2016)

Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression
por: Giannios, Ioannis, et al.
Publicado: (2019)

UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma
por: Kostyrko, Kaja, et al.
Publicado: (2023)

Phenformin alone or combined with gefitinib inhibits bladder cancer via AMPK and EGFR pathways
por: Huang, Yanjun, et al.
Publicado: (2018)

Phenformin and metformin inhibit growth and migration of LN229 glioma cells in vitro and in vivo
por: Wang, Yanmin, et al.
Publicado: (2018)

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis
por: LaMoia, Traci E., et al.
Publicado: (2022)

KRAS-driven ROS promote malignant transformation
por: Suh, Yongjoon, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_pl6q0g9k45fp38p8r47ecte8q0