Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor

Alpha one antitrypsin (α1AT), a serine proteinase inhibitor primarily produced by the liver, protects pulmonary tissue from neutrophil elastase digestion. Mutations of the SERPINA1 gene results in a misfolded α1AT protein which aggregates inside hepatocytes causing cellular damage. Therefore, inhibi...

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Detalles Bibliográficos
Autores principales: Rao, Lang, Xu, Yi, Reineke, Lucas Charles, Bhattacharya, Abhisek, Tyryshkin, Alexey, Shin, Jin Na, Eissa, N. Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352753/
https://www.ncbi.nlm.nih.gov/pubmed/32560429
http://dx.doi.org/10.3390/ijms21124318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352753/
https://www.ncbi.nlm.nih.gov/pubmed/32560429
http://dx.doi.org/10.3390/ijms21124318

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