Tracing Nutrient Flux Following Monocarboxylate Transporter-1 Inhibition with AZD3965

The monocarboxylate transporter 1 (MCT1) is a key element in tumor cell metabolism and inhibition of MCT1 with AZD3965 is undergoing clinical trials. We aimed to investigate nutrient fluxes associated with MCT1 inhibition by AZD3965 to identify possible biomarkers of drug action. We synthesized an (...

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Detalles Bibliográficos
Autores principales: Braga, Marta, Kaliszczak, Maciej, Carroll, Laurence, Schug, Zachary T., Heinzmann, Kathrin, Baxan, Nicoleta, Benito, Adrian, Valbuena, Gabriel N., Stribbling, Stephen, Beckley, Alice, Mackay, Gillian, Mauri, Francesco, Latigo, John, Barnes, Chris, Keun, Hector, Gottlieb, Eyal, Aboagye, Eric O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352845/
https://www.ncbi.nlm.nih.gov/pubmed/32604836
http://dx.doi.org/10.3390/cancers12061703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352845/
https://www.ncbi.nlm.nih.gov/pubmed/32604836
http://dx.doi.org/10.3390/cancers12061703

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