CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis

Chromosomal rearrangements of the mixed lineage leukaemia (MLL, also known as KMT2A) gene on chromosome 11q23 are amongst the most common genetic abnormalities observed in human acute leukaemias. MLL rearrangements (MLLr) are the most common cytogenetic abnormalities in infant and childhood acute my...

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Detalles Bibliográficos
Autores principales: Sarrou, Evgenia, Richmond, Laura, Carmody, Ruaidhrí J., Gibson, Brenda, Keeshan, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352880/
https://www.ncbi.nlm.nih.gov/pubmed/32549410
http://dx.doi.org/10.3390/ijms21124266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352880/
https://www.ncbi.nlm.nih.gov/pubmed/32549410
http://dx.doi.org/10.3390/ijms21124266

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