Mono-PEGylation of a Thermostable Arginine-Depleting Enzyme for the Treatment of Lung Cancer

L-arginine (L-Arg) depletion induced by randomly PEGylated arginine deiminase (ADI-PEG20) can treat arginosuccinate synthase (ASS)-negative cancers, and ADI-PEG20 is undergoing phase III clinical trials. Unfortunately, ASS-positive cancers are resistant to ADI-PEG20. Moreover, the yield of ADI produ...

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Detalles Bibliográficos
Autores principales: Chung, Sai-Fung, Kim, Chi-Fai, Kwok, Sui-Yi, Tam, Suet-Ying, Chen, Yu Wai, Chong, Hiu-Chi, Leung, Siu-Lun, So, Pui-Kin, Wong, Kwok-Yin, Leung, Yun-Chung, Lo, Wai-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353006/
https://www.ncbi.nlm.nih.gov/pubmed/32545874
http://dx.doi.org/10.3390/ijms21124234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353006/
https://www.ncbi.nlm.nih.gov/pubmed/32545874
http://dx.doi.org/10.3390/ijms21124234

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