Cargando…

Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in Mitosis

The epigenetic reader BRD4 binds acetylated histones and plays a central role in controlling cellular gene transcription and proliferation. Dysregulation of BRD4′s activity has been implicated in the pathogenesis of a wide variety of cancers. While blocking BRD4 interaction with acetylated histones...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Ranran, Yang, June F., Ho, Flora, Robertson, Erle S., You, Jianxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353023/ https://www.ncbi.nlm.nih.gov/pubmed/32575711 http://dx.doi.org/10.3390/cancers12061637

Ejemplares similares

Analysis of the Papillomavirus E2 and Bromodomain Protein Brd4 Interaction Using Bimolecular Fluorescence Complementation
por: Helfer, Christine M., et al.
Publicado: (2013)

Bromodomain-containing protein 4 (BRD4) as an epigenetic regulator of fatty acid metabolism genes and ferroptosis
por: Yang, Minghua, et al.
Publicado: (2022)

Bromodomain Protein Brd4 Plays a Key Role in Merkel Cell Polyomavirus DNA Replication
por: Wang, Xin, et al.
Publicado: (2012)

The Cellular Bromodomain Protein Brd4 has Multiple Functions in E2-Mediated Papillomavirus Transcription Activation
por: Helfer, Christine M., et al.
Publicado: (2014)

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis
por: Roberts, Thomas C., et al.
Publicado: (2017)

Targeting bromodomain-containing protein 4 (BRD4) inhibits MYC expression in colorectal cancer cells
por: Otto, C., et al.
Publicado: (2019)

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
por: Zengerle, Michael, et al.
Publicado: (2015)

A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression
por: Zhou, Zijun, et al.
Publicado: (2020)

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors
por: Ember, Stuart W. J., et al.
Publicado: (2014)

Bromodomain-containing subunits BRD1, BRD2, and BRD13 are required for proper functioning of SWI/SNF complexes in Arabidopsis
por: Jarończyk, Kamila, et al.
Publicado: (2021)

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function
por: Cribbs, Adam P., et al.
Publicado: (2021)

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell
por: Deeney, Jude T., et al.
Publicado: (2016)

The bromodomain protein BRD4 regulates splicing during heat shock
por: Hussong, Michelle, et al.
Publicado: (2017)

Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4
por: Sakamaki, Jun-Ichi, et al.
Publicado: (2017)

Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival
por: Kannan-Sundhari, Abhiraami, et al.
Publicado: (2020)

Bromodomain-containing protein 7 (BRD7) as a potential tumor suppressor in hepatocellular carcinoma
por: Chen, Chang-Long, et al.
Publicado: (2016)

The Bromodomain Protein Brd4 Insulates Chromatin from DNA Damage Signaling
por: Floyd, Scott R., et al.
Publicado: (2013)

Identification of bromodomain-containing protein 4 (BRD4) as a novel marker and epigenetic target in mast cell leukemia
por: Wedeh, Ghaith, et al.
Publicado: (2015)

The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility
por: Leser, Katja, et al.
Publicado: (2012)

Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
por: Sakamaki, Jun-ichi, et al.
Publicado: (2017)

Pyronaridine as a Bromodomain-Containing Protein 4-N-Terminal Bromodomain (BRD4-BD1) Inhibitor: In Silico Database Mining, Molecular Docking, and Molecular Dynamics Simulation
por: Ibrahim, Mahmoud A. A., et al.
Publicado: (2023)

Bromodomain Containing Protein 4 (BRD4) Regulates Expression of its Interacting Coactivators in the Innate Response to Respiratory Syncytial Virus
por: Xu, Xiaofang, et al.
Publicado: (2021)

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
por: Segatto, Marco, et al.
Publicado: (2017)

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes
por: Hügle, Martin, et al.
Publicado: (2016)

Impact of bromodomain‐containing protein 4 (BRD4) and intestine‐specific homeobox (ISX) expression on the prognosis of patients with hepatocellular carcinoma' for better clarity
por: Chuang, Kai‐Ting, et al.
Publicado: (2021)

Alchemical Free Energy Methods Applied to Complexes of the First Bromodomain of BRD4
por: Guest, Ellen E., et al.
Publicado: (2022)

Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription
por: Nagarajan, Sankari, et al.
Publicado: (2014)

Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection
por: Milner, J. Justin, et al.
Publicado: (2021)

Bromodomain Protein BRD4-Mediated Mutant p53 Transcription Promotes TNBC Progression
por: Zhou, Julie Xia, et al.
Publicado: (2022)

Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells
por: Sui, Shiyao, et al.
Publicado: (2019)

Abrogation of Brd4 cellular function contributes to the oncogenic mechanisms of translocation t(15;19)-associated carcinoma
por: Wang, Ranran, et al.
Publicado: (2013)

Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis
por: Klein, Kerstin, et al.
Publicado: (2018)

Epigenetic and pharmacological control of pigmentation via Bromodomain Protein 9 (BRD9)
por: Basuroy, Tupa, et al.
Publicado: (2022)

Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity
por: Wang, Liu, et al.
Publicado: (2021)

The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response
por: Hussong, M, et al.
Publicado: (2014)

Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4
por: Gutbrod, M. J., et al.
Publicado: (2022)

Native Mass Spectrometry of BRD4 Bromodomains Linked to a Long Disordered Region
por: Azegami, Nanako, et al.
Publicado: (2022)

Insights into the Ligand Binding to Bromodomain-Containing Protein 9 (BRD9): A Guide to the Selection of Potential Binders by Computational Methods
por: De Vita, Simona, et al.
Publicado: (2021)

Drug Discovery Targeting Bromodomain-Containing Protein 4
por: Liu, Zhiqing, et al.
Publicado: (2017)

Bromodomain protein BRD4 is an epigenetic activator of B7-H6 expression in acute myeloid leukemia
por: Baragaño Raneros, Aroa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_13dksjgfg26vef2fth8se2kevi