Integrated analysis of optical mapping and whole-genome sequencing reveals intratumoral genetic heterogeneity in metastatic lung squamous cell carcinoma

BACKGROUND: Intratumoral heterogeneity is a crucial factor to the outcome of patients and resistance to therapies, in which structural variants play an indispensable but undiscovered role. METHODS: We performed an integrated analysis of optical mapping and whole-genome sequencing on a primary tumor...

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Detalles Bibliográficos
Autores principales: Peng, Yizhou, Yuan, Chongze, Tao, Xiaoting, Zhao, Yue, Yao, Xingxin, Zhuge, Lingdun, Huang, Jianwei, Zheng, Qiang, Zhang, Yue, Hong, Hui, Chen, Haiquan, Sun, Yihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354123/
https://www.ncbi.nlm.nih.gov/pubmed/32676329
http://dx.doi.org/10.21037/tlcr-19-401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354123/
https://www.ncbi.nlm.nih.gov/pubmed/32676329
http://dx.doi.org/10.21037/tlcr-19-401

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