Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking

Adeno-associated viruses (AAVs) are small, non-pathogenic ssDNA viruses being used as therapeutic gene delivery vectors for the treatment of a variety of monogenic diseases. An obstacle to successful gene delivery is inefficient capsid trafficking through the endo/lysosomal pathway. This study aimed...

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Detalles Bibliográficos
Autores principales: Lins-Austin, Bridget, Patel, Saajan, Mietzsch, Mario, Brooke, Dewey, Bennett, Antonette, Venkatakrishnan, Balasubramanian, Van Vliet, Kim, Smith, Adam N., Long, Joanna R., McKenna, Robert, Potter, Mark, Byrne, Barry, Boye, Sanford L., Bothner, Brian, Heilbronn, Regine, Agbandje-McKenna, Mavis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354436/
https://www.ncbi.nlm.nih.gov/pubmed/32575696
http://dx.doi.org/10.3390/v12060668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354436/
https://www.ncbi.nlm.nih.gov/pubmed/32575696
http://dx.doi.org/10.3390/v12060668

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