DNA-induced 2′3′-cGAMP enhances haplotype-specific human STING cleavage by dengue protease

The cytosolic DNA sensor cGMP-AMP synthase (cGAS) synthesizes the noncanonical cyclic dinucleotide 2′3′-cGAMP to activate the adaptor protein stimulator of IFN genes (STING), thus awakening host immunity in response to DNA pathogen infection. However, dengue virus (DENV), an RNA virus without a DNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Su, Chan-I, Kao, Yu-Ting, Chang, Chao-Chen, Chang, Yao, Ho, Tzong-Shiann, Sun, H. Sunny, Lin, Yi-Ling, Lai, Michael M. C., Liu, Yu-Huei, Yu, Chia-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354927/
https://www.ncbi.nlm.nih.gov/pubmed/32576686
http://dx.doi.org/10.1073/pnas.1922243117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354927/
https://www.ncbi.nlm.nih.gov/pubmed/32576686
http://dx.doi.org/10.1073/pnas.1922243117

Ejemplares similares