Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

Huntington disease (HD) is caused by an expansion mutation of the N-terminal polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable damage to the brain’s striatum, thereby affecting motor, psychiatric, and cognitive functions. The striatal damage and progression...

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Detalles Bibliográficos
Autores principales: Sharma, Manish, Rajendrarao, Sumitha, Shahani, Neelam, Ramírez-Jarquín, Uri Nimrod, Subramaniam, Srinivasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354937/
https://www.ncbi.nlm.nih.gov/pubmed/32581130
http://dx.doi.org/10.1073/pnas.2002144117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354937/
https://www.ncbi.nlm.nih.gov/pubmed/32581130
http://dx.doi.org/10.1073/pnas.2002144117

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