The stem cell marker Prom1 promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling

Axon regeneration is regulated by a neuron-intrinsic transcriptional program that is suppressed during development but that can be reactivated following peripheral nerve injury. Here we identify Prom1, which encodes the stem cell marker prominin-1, as a regulator of the axon regeneration program. Pr...

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Detalles Bibliográficos
Autores principales: Lee, Jinyoung, Shin, Jung Eun, Lee, Bohm, Kim, Hyemin, Jeon, Yewon, Ahn, Seung Hyun, Chi, Sung Wook, Cho, Yongcheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355016/
https://www.ncbi.nlm.nih.gov/pubmed/32554499
http://dx.doi.org/10.1073/pnas.1920829117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355016/
https://www.ncbi.nlm.nih.gov/pubmed/32554499
http://dx.doi.org/10.1073/pnas.1920829117

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