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The stem cell marker Prom1 promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling
Axon regeneration is regulated by a neuron-intrinsic transcriptional program that is suppressed during development but that can be reactivated following peripheral nerve injury. Here we identify Prom1, which encodes the stem cell marker prominin-1, as a regulator of the axon regeneration program. Pr...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355016/ https://www.ncbi.nlm.nih.gov/pubmed/32554499 http://dx.doi.org/10.1073/pnas.1920829117 |